Urusei Yatsura

Ataru runs away from home, unable to stand the pressure of living with Lum, and bumps into a beautiful lady named Sakura, who takes him to her shrine for exorcism. Sakura becomes Tomobiki High School’s nurse, and her beauty makes all the boys deliberately injure themselves in order to go see her. But later, they get really sick, which might be connected to Ataru, who oddly enough wants to avoid her.